{"id":3652,"date":"2023-03-03T14:49:35","date_gmt":"2023-03-03T13:49:35","guid":{"rendered":"https:\/\/iuc-aphp-sorbonneuniversite.com\/structure-recherche\/cimi-paris-centre-dimmunology-and-infectious-diseases\/"},"modified":"2023-03-03T14:49:35","modified_gmt":"2023-03-03T13:49:35","slug":"cimi-paris-centre-dimmunology-and-infectious-diseases","status":"publish","type":"structure-recherche","link":"https:\/\/iuc-aphp-sorbonneuniversite.com\/en\/structure-recherche\/cimi-paris-centre-dimmunology-and-infectious-diseases\/","title":{"rendered":"Cimi Paris – Center for Immunology and Infectious Diseases"},"content":{"rendered":"
\n

Summary of the activity<\/h2>\n

The Center for Immunology and Infectious Diseases (Cimi) is a joint research unit created in 2014 and affiliated with Sorbonne University, Inserm and CNRS. The Cimi is located on the campus of the Faculty of Medicine of Sorbonne University on the site of the Piti\u00e9-Salp\u00eatri\u00e8re in Paris. This location creates a strong dynamic of exchanges between the research teams and the hospital services. Approximately 150 people work at the Cimi, including researchers, teachers, technical and research support staff. Research at the Cimi explores immune system functions and host-pathogen interactions, and seeks to develop new therapeutic strategies in the field of immunology and infectious diseases. Themes: immunology, inflammation, immuno-oncology, microbiology, host-pathogen interactions, antibiotic resistance, vaccinology.<\/p>\n

 <\/p>\n

Site\/location and physical address<\/h2>\n<\/div>\n

Piti\u00e9 Salp\u00eatri\u00e8re Hospital
\nFaculty of Medicine
\nSorbonne University
\n91-105 boulevard de l’H\u00f4pital – 75013 PARIS<\/p>\n

 <\/p>\n

\n

Website<\/h2>\n

cimiparis.fr<\/a><\/p>\n

 <\/p>\n<\/div>\n

\n

Contact<\/h2>\n

Mail: <\/strong>cimi-paris@upmc.fr<\/a><\/p>\n

Telephone:<\/strong> ‘+ 33(0)1.42.17.74.60 \/ 61<\/p>\n

 <\/p>\n

Guardianship<\/h2>\n

INSERM and Sorbonne University<\/strong><\/p>\n

 <\/p>\n

Director \/ Head of structure<\/h2>\n

COMBADIERE Christophe<\/strong><\/p>\n

 <\/p>\n

 <\/p>\n

Research units<\/h2>\n
\n<\/div>\n

Chemokines, Phagocytes and Inflammation<\/h3>\n
\n

The work of our team focuses on the origin and function of myeloid cells in infectious diseases and cancer. The aim is to decipher the regulation of pro- and anti-inflammatory activities delivered by these cells of the innate immune system.<\/p>\n

 <\/p>\n

Website
\n<\/strong><\/p>\n

https:\/\/cimiparis.fr\/equipes\/boissonnas-alexandre\/<\/a><\/p>\n

 <\/p>\n

Manager \/ Team Leader<\/strong><\/p>\n

Behazine Combadi\u00e8re<\/p>\n<\/div>\n

\n
\n<\/div>\n

Immunity and vaccination<\/h3>\n
\n

The work of our team focuses on the origin and function of myeloid cells in infectious diseases and cancer. The aim is to decipher the regulation of pro- and anti-inflammatory activities delivered by these cells of the innate immune system.<\/p>\n

 <\/p>\n

Website<\/strong><\/p>\n

https:\/\/cimiparis.fr\/equipes\/combadiere-behazine\/<\/a><\/p>\n<\/div>\n

\n

 <\/p>\n

Manager \/ Team Leader<\/strong><\/p>\n

Behazine Combadi\u00e8re<\/p>\n

\n
\n<\/div>\n

Immune microenvironment and immunotherapy<\/h3>\n
\n

Vaccinology is a multidisciplinary field that is now progressing towards the discovery of early biomarkers of vaccine efficacy in order to accelerate vaccine development. Humoral responses are considered to be markers of effective immune responses for protection, but these responses are detected months after vaccination.<\/p>\n

 <\/p>\n

Website<\/strong><\/p>\n

cimiparis.fr\/teams\/god-nosjean-marie-caroline\/<\/a><\/p>\n

 <\/p>\n

Manager \/ Team Leader<\/strong><\/p>\n

Marie-Caroline Dieu-Nosjean<\/p>\n

\n<\/div>\n<\/div>\n
\n
\n

Immunoregulation and Therapy of Autoimmune Diseases and Cancer<\/h3>\n
\n

We specialize in the study of CD4+Foxp3+ regulatory T cells (Tregs) in mice, humanized mice and humans, and of certain cytokines. We are working on the role of metabolism, co-stimulatory\/co-inhibitory signals, IL-12 and TNF family cytokines and novel markers of Tregs in the control of autoimmune diseases and cancers.<\/p>\n

 <\/p>\n

Website<\/strong><\/p>\n

cimiparis.fr\/teams\/salomon-benoit\/<\/a><\/p>\n

 <\/p>\n

Manager \/ Team Leader<\/strong><\/p>\n

Beno\u00eet Salomon<\/p>\n

\n<\/div>\n<\/div>\n
\n
\n
\n

Immunopathogenesis of viral infections and immune aging<\/h3>\n
\n

We perform comparative studies of immunological and inflammatory attributes in settings with signs of immune aging, including advanced age, certain viral infections, and reduced thymic activity.<\/p>\n

 <\/p>\n

Website<\/strong><\/p>\n

https:\/\/cimiparis.fr\/equipes\/delphine-sauce\/<\/a><\/p>\n

 <\/p>\n

Manager \/ Team Leader<\/strong><\/p>\n

Delphine Sauce<\/p>\n

\n<\/div>\n<\/div>\n
\n
\n

Signaling and Pathogenesis<\/h3>\n
\n

Research on the activation and regulation of the immune system is carried out at the molecular and cellular level, but also by using animal models and by studying clinical situations. Because of its homology with NEMO (essential modulator of the NF-\uf06bB pathway), our studies on the NF-\uf06bB pathway led us to focus on Optineurin which is involved in autophagy\/Mitophagy. By integrating dynamics, structure, and cellular and molecular biology, we address fundamental questions about how fungal infections are initiated and lead to disease.<\/p>\n

 <\/p>\n

Website<\/strong><\/p>\n

cimiparis.fr\/teams\/robert-weil\/<\/a><\/p>\n

 <\/p>\n

Manager \/ Team Leader<\/strong><\/p>\n

Robert Weil<\/p>\n

\n<\/div>\n<\/div>\n
\n
\n

Immunity, infection and cancer of NK& T cells<\/h3>\n<\/div>\n
\n
\n
\n

Through conventional and innovative approaches, we are interested in unraveling the role of innate (NK cells) and adaptive (T cells) cellular immunity in different human pathologies (viral infections, autoimmune and psychiatric diseases or cancer) in close collaboration with clinical services.<\/p>\n

 <\/p>\n

Website<\/strong><\/p>\n

cimiparis.fr\/teams\/vieillard-vincent\/<\/a><\/p>\n

 <\/p>\n

Manager \/ Team Leader<\/strong><\/p>\n

Vincent Vieillard<\/p>\n

 <\/p>\n

\n<\/div>\n<\/div>\n
\n
\n
\n

Immunity, infection and cancer of NK& T cells<\/h3>\n<\/div>\n<\/div>\n
\n
\n
\n
\n

We have been studying for many years the immune response directed against viruses, recently against SARSCov2, or that associated with autoimmunity or immune deficiencies. We postulate that antibodies targeting autoantigens (active as specific competitors), or used to redirect regulatory T cells could represent new forms of personalized therapies.<\/p>\n

 <\/p>\n

Website<\/strong><\/p>\n

cimiparis.fr\/teams\/guy-gorochov\/<\/a><\/p>\n

 <\/p>\n

Manager \/ Team Leader<\/strong><\/p>\n

Guy Gorochov<\/p>\n

\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n
\n
\n
\n

Immunity & microbial ecology<\/h3>\n<\/div>\n<\/div>\n
\n
\n
\n
\n

Initial colonization of the human intestine. We study the interactions between environmental exposure, gut microbiota and host immunity to understand the homeostasis of healthy gut microbiota and human pathophysiology. Our objective is to decipher the role of adaptive immunity on the homeostasis of the intestinal microbiota, with a particular focus on microbiota-specific immunoglobulin A (immuno-microbiota).<\/p>\n

 <\/p>\n

Website<\/strong><\/p>\n

cimiparis.fr\/teams\/martin-larsen\/<\/a><\/p>\n

 <\/p>\n

Manager \/ Team Leader<\/strong><\/p>\n

Martin Larsen<\/p>\n

\n<\/div>\n<\/div>\n
\n
\n
\n
\n

Emergence and spread of multidrug resistance to antibiotics<\/h3>\n<\/div>\n<\/div>\n
\n
\n
\n
\n

Our team seeks to understand the mechanisms of emergence and diffusion of bacterial multidrug resistance to antibiotics, particularly in mycobacteria, including Mycobacterium tuberculosis (Mtb), and enterobacteria, including Klebsiella pneumoniae (KP).<\/p>\n

 <\/p>\n

Website<\/strong><\/p>\n

cimiparis.fr\/teams\/aubry-alexandra\/<\/a><\/p>\n

 <\/p>\n

Manager \/ Team Leader<\/strong><\/p>\n

Alexandra Aubry<\/p>\n

\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n
\n
\n
\n
\n
\n
\n
\n

Biology and immunology of malaria<\/h3>\n<\/div>\n<\/div>\n
\n
\n
\n
\n

Our research aims at elucidating the fundamental aspects of the infection of the liver by Plasmodium, the agent of malaria, in order to identify and validate new vaccine and drug targets. Building on our expertise in sporozoite and liver stage biology and our discovery of host and parasite factors that play a key role in infection, we are developing projects exploring the mechanisms of sporozoite entry, development of liver forms and hypnozoite formation, gene regulation during transmission, and immunity to liver stages of infection<\/p>\n

 <\/p>\n

Website<\/strong><\/p>\n

cimiparis.fr\/teams\/silvie-olivier\/<\/a><\/p>\n

 <\/p>\n

Manager \/ Team Leader<\/strong><\/p>\n

Olivier Silvie<\/p>\n

\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n
\n
\n

Dynamics, structure and molecular biology of fungal invasion<\/h3>\n<\/div>\n<\/div>\n
\n
\n
\n
\n

Our research aims at elucidating the fundamental aspects of the infection of the liver by Plasmodium, the agent of malaria, in order to identify and validate new vaccine and drug targets. Building on our expertise in sporozoite and liver stage biology and our discovery of host and parasite factors that play a key role in infection, we are developing projects exploring the mechanisms of sporozoite entry, development of liver forms and hypnozoite formation, gene regulation during transmission, and immunity to liver stages of infection<\/p>\n

 <\/p>\n

Website<\/strong><\/p>\n

cimiparis.fr\/teams\/weiner-allon\/<\/a><\/p>\n

 <\/p>\n

Manager \/ Team Leader<\/strong><\/p>\n

Allon Weiner<\/p>\n

\n<\/div>\n<\/div>\n
<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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