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Summary of the activity
The Sorbonne University Clinical Research Groups (GRC SU) bring together, as a priority, university hospital investigators on a defined theme, the leader not being attached to a research structure under the supervision of Sorbonne University. Our medical school has issued its 3rd call for applications for SU GRC labeling in 2019.
Labeling Objectives:
- Recognize quality structures with a high level of expertise in the field of clinical research
- Strengthen the national and international academic visibility of Clinical Research Groups
This labeling allows:
- to welcome master students;
- to apply for the doctoral projects of the Sorbonne University doctoral schools;
- Have SU manage funding from public agencies, businesses, or nonprofit organizations
Site/location and physical address
Pitié Salpêtrière Hospital – Saint-Antoine Hospital – Faculty of Medicine – Sorbonne University
91-105 boulevard de l’Hôpital – 75013 PARIS
Website
sante.sorbonne-universite.fr/recherche-0/les-groupes-de-recherche-clinique
Research units
Endometriosis Expert Centre – GRC 6 : C3E
The GRC was created in 2011 on the theme of endometriosis incorporating various specialties: gynecological surgeons, assisted reproduction specialists, endocrinologists, radiologists, anatomical pathologists, urological and digestive surgeons, psychologists, pain specialists and finally alternative medicine (osteopathy etc…). This led to the creation of the first multidisciplinary consultation meeting (RCP) in endometriosis in France.
Website
sante.sorbonne-universite.fr/structures-de-recherche/centre-expert-en-endometriose
Website
Tenon Hospital
4 rue de la Chine 75020 PARISResponsible/ Team Leader
Cyril Touboul
Contact
secretariat.touboul@tnn.aphp.fr
Emergency and Resuscitation Biomarkers – GRC 14: BIOSFAST
The GRC-14 BIOSFAST is dedicated to the study of emergency and resuscitation biomarkers and in particular the clinical validation of their added value, both on a diagnostic and prognostic level. In areas such as sepsis and infection, head trauma, cardiac biomarkers and stress biomarkers, GRC-14 brings its expertise and in particular its clinical services, including 3 adult emergency services, to set up and conduct clinical studies in order to validate current biomarkers but also new biomarkers at the R&D stage.
Website
sante.sorbonne-universite.fr/structures-de-recherche/biosfast
Site
Pitié Salpêtrière Hospital
47-83 bd de l’Hôpital 75013 Paris
Manager / Team Leader
Pierre Hausfater
Contact
pierre.hausfater@aphp.fr
Analysis, Research, Development and Evaluation in Endourology and Urinary Lithiasis – GRC 20 : ARDELURO
The GRC 10 Lithiasis aims to evaluate the risk factors of urinary lithiasis (particularly the risk factors of hypercalciuria and the evaluation of new technologies in EndoUrology for the urological treatment of urinary stones
Renal lithiasis is a public health problem It affects 10 of the French population, 2 men for 1 woman, average age 40 years It is a recurrent pathology with an estimated rate of 50 at 5 years and 70 at 10 years It is responsible for 1 to 2 of the emergency room visits related to renal colic that it generates.
The main risk factors are related to dietary habits and the resulting hypercalciuria.
The evaluation of these risk factors in order to prevent lithiasis and the development of stone treatment tools is now essential for the management of lithiasis patients.
Website
sante.sorbonne-universite.fr/structures-de-recherche/ardeluro
Site
Pitié Salpêtrière Hospital
47-83 bd de l’Hôpital
75013 Paris
Manager / Team Leader
Olivier TRAXER
Contact
olivier.traxer@sorbonne-universite.fr
Alzheimer Precision Medicine – GRC21: APM
In recent years, technological developments in the field of neuroimaging (Fluorodeoxyglucose PET amyloid PET) and biology (measurement of Tau protein and amyloid peptide concentrations in cerebrospinal fluid and more recently in blood, with markers of inflammation or neuronal death) have revolutionized the diagnostic strategy, prognostic anticipation, and therapeutic perspectives in this disease. The specificity and sensitivity of each of these biomarkers remain to be demonstrated. Some of them are expensive or invasive (lumbar puncture). Blood markers may help to overcome these difficulties.
Website
sante.sorbonne-universite.fr/structures-de-recherche/apm
Site
Pitié Salpêtrière Hospital
47-83 bd de l’Hôpital
75013 Paris
Manager / Team Leader
Bruno DUBOIS
Contact
bruno.dubois@aphp.fr
Neuro-machine interface – GRC 23 : NeurON
The INTERFACE NEURO-MACHINE program is a clinical research group bringing together all the multidisciplinary expertise of Sorbonne University in Neuro Machine Interface. This program allows us to create a common dynamic, to decompartmentalize current therapeutic strategies, and to improve our medical and scientific collaborations. The goal is to design, evaluate and integrate new technologies and to develop innovative therapeutic strategies for the improvement of neuronal functions. This program brings together 44 scientific projects and more than sixty neuroscientists, neurobiologists, engineers, and researchers in the humanities.
Website
sante.sorbonne-universite.fr/structures-de-recherche/neuron
Website
Pitié Salpêtrière Hospital
47-83 bd de l’Hôpital
75013 Paris
Manager / Team Leader
Bruno DUBOIS
Contact
bruno.dubois@aphp.fr
Image-guided medicine for women and children – GRC 26: IMAGES
The theme at the heart of the IMAGES clinical research group is image-assisted medicine. The term “image” is taken in a broad sense to include ultrasound imaging, radiographic imaging based on ionizing radiation, magnetic resonance imaging and other imaging modalities. The GRC brings together specialties with strong synergies, using images in routine and research, and involved in the care of women, the fetus and the child.
Site
Trousseau Hospital
26 avenue du Dr Arnold Netter
75012 PARIS
Manager / Team Leader
Ferdinand DHOMBRES
Contact
alexandre.carpentier@aphp.fr
Cardio Oncology Research Group – GRC 27 : GRECO
The Cardio-Oncology Clinical Research Group ( aims to identify the main determinants of cardiac toxicity of anthracycline chemotherapies (targeted therapies, androgen deprivation and immunotherapies), to characterize the thrombo-embolic risk of cancer patients and to identify strategies to prevent these cardiovascular toxicities and complications. This group will rely on the expertise of each of its members in the field of imaging (S. EDERHY, Cardio-Oncology Unit, Sorbonne University and Cardiology Department, Hôpital Saint-Antoine), translational pharmacology combining basic pharmacology, pharmacoepidemiology and pharmacovigilance (JE SALEM, Cardio-Oncology Unit, Sorbonne University and Pharmacology Department, Hôpital Pitié-Salpêtrière) and haemostasis (Corinne FRERE, Cardio-Oncology Unit and Biological Hematology Department, Hôpital Pitié-Salpêtrière).
Website
sante.sorbonne-universite.fr/structures-de-recherche/grc-27-greco
Site
Hôpital Saint-Antoine
27 rue de Chaligny
75012 Paris
Manager / Team Leader
Stéphane EDERHY
Amyloidosis AA Sorbonne University Clinical Research Group (GRAASU) – GRC 28 : GRAASU
AA amyloidosis is a rare heterogeneous disease related to the deposition of an inflammatory protein, SAA, in tissues. It complicates chronic inflammatory states and has a significant morbi/mortality. GRAASU will be a unique structure composed of all the clinical and medico-technical services involved in the management of AA amyloidosis at Sorbonne University. Its objectives are to create an epidemiological database, to develop more efficient diagnostic and monitoring tools, to better understand the physiopathology and to set up therapeutic trials. Already supported by the French amyloidosis patient association, it aims to be the national and European leader in AA amyloidosis in terms of the number of patients included and the synergy of the specialists involved.
Site
Tenon Hospital
Anatomical Pathology Laboratory
4 rue de la Chine 75020 PARIS
Manager / Team Leader
Pr Sophie Georgin Lavialle
Pr David BUOB
Contact
sophie.georgin-lavialle@aphp.fr
Clinical Research Group in Perioperative Anesthesia and Resuscitation – GRC 29 : ARPE
AA amyloidosis is a rare heterogeneous disease related to the deposition of an inflammatory protein, SAA, in tissues. It complicates chronic inflammatory states and has a significant morbi/mortality. GRAASU will be a unique structure composed of all the clinical and medico-technical services involved in the management of AA amyloidosis at Sorbonne University. Its objectives are to create an epidemiological database, to develop more efficient diagnostic and monitoring tools, to better understand the physiopathology and to set up therapeutic trials. Already supported by the French amyloidosis patient association, it aims to be the national and European leader in AA amyloidosis in terms of the number of patients included and the synergy of the specialists involved.
Site
Pitié Salpêtrière Hospital
Surgical Resuscitation
Department of Anesthesia and Intensive Care
47-83 bd de l’Hôpital 75013 Paris
Manager / Team Leader
Jean-Michel CONSTANTIN
Contact
jean-michel.constantin-ext@aphp.fr
Study Group on Idiopathic Intracranial HyperTension (EHTIC) – GRC 30 : RESPIRE
The ARPE GRC is the convergence of two strong axes: acute respiratory failure and neuroscience. Its mission is to promote clinical and epidemiological research and to encourage translational projects in a theme encompassing all critical care with public and private partnerships. An important place is left to para-medical research. It welcomes students from different backgrounds and accompanies them in their research masters or university thesis.
Site
Pitié Salpêtrière Hospital
Surgical Resuscitation
Department of Anesthesia and Intensive Care
47-83 bd de l’Hôpital 75013 Paris
Manager / Team Leader
Matthieu SCHMIDT
Phone
+33 1 42 16 29 37
Contact
matthieu.schmidt@aphp.fr
Study Group on Idiopathic Intracranial HyperTension (EHTIC) – GRC 30 : RESPIRE
Acute respiratory failure (ARF) is the leading cause of admission to neonatal, pediatric and adult intensive care units. The objective of the RESPIRE research group is to pool the clinical research expertise of the Intensive Care Medicine departments of the University Hospital on the subject of ARF. This GRC is part of a cross-disciplinary approach to the age of the patients concerned (from newborns to the elderly), the ventilatory supports used, and the groups of patients studied (community, neuromuscular, immunocompromised).
Site
Pitié Salpêtrière Hospital
Surgical Resuscitation
Department of Anesthesia and Intensive Care
47-83 bd de l’Hôpital 75013 Paris
Manager / Team Leader
Matthieu SCHMIDT
Phone
+33 1 42 16 29 37
Contact
matthieu.schmidt@aphp.fr
Idiopathic Intracranial HyperTension Study Group (IHTIC) – GRC 31
For several decades, obesity has been on the rise in all industrialized countries. The incidence of idiopathic intracranial hypertension (IIH) is closely linked to that of obesity, resulting in a major functional handicap related to chronic disabling headaches and sometimes irreversible visual sequelae (visual field amputation, reduced visual acuity, optic atrophy to blindness) observed in nearly 25% of patients. The pathophysiology of HTIC remains mysterious at present but could be fundamentally changed by recent data concerning the cerebral mechanisms of veno-glymphatic drainage. The aim of the GRC E HTIC is to create a unique and legible network in France for the management of HTIC, bringing together all the players involved in the care of these patients (interventional neuroradiologists, neurosurgeons, neurologists, endocrinologists). At the interface of the 3 University Hospital Institutes of Sorbonne University (IHU FOReSIGHT ICM, and ICAN), the EHTIC GRC combines care, clinical research and fundamental research activities unique in France on this chronic and disabling pathology.
Site
Hôpital des Quinze-Vingts
28 rue Charenton
75012 PARIS, France
Manager / Team Leader
Valérie TOUITOU
Contact
valerie.touitou@sorbonne-universite.fr
Transplantation and Innovative Corneal Therapies (TTIC) – GRC 32 : TTIC
Severe corneal pathologies are one of the main causes of blindness in the world. The objective of GRC 32 is to participate in the development of innovative treatments for blinding corneal diseases through prospective clinical trials and long-term longitudinal follow-up of large cohorts of treated patients. These innovative treatments include transplantation, cell therapy, regenerative therapies for corneal innervation, and innovative treatments for keratoconus.
Site
Hôpital des Quinze-Vingts
28 rue Charenton
75012 PARIS, France
Manager / Team Leader
Vincent BORDERIE
Contact
selimane@15-20.fr
Robotics and Surgical Innovations – GRC 33 : RIC
The development of new technologies is a crucial element in the development of surgical practice. The Clinical Research Group “Surgical Robotics and Innovation” GRC-RIC promotes preclinical and clinical research in all surgical fields and aims to integrate new technologies such as robotics, surgical navigation, simulation, augmented reality and artificial intelligence. The GRC-RIC facilitates the hosting and supervision of young clinical researchers on these themes. It encourages the response to internal and external calls for tenders to Sorbonne University for the realization of clinical research projects related to surgical innovation. The GRC-RIC ensures the national and international visibility of Sorbonne University in terms of translational research and surgical innovation.
Website
sante.sorbonne-universite.fr/structures-de-recherche/grc-33-ric
Site
Trousseau Hospital
Department of Pediatric Orthopedic and Reconstructive Surgery
26 avenue du Dr Arnold Netter
75012 PARIS
Manager / Team Leader
Raphaël VIALLE
Contact
raphael.vialle@aphp.fr