St. Antoine Research Center

Summary of the activity

The ASRC has a very strong potential for both basic and translational biomedical research. The research work is carried out in collaboration with the clinical and biological services of the Saint-Antoine-Tenon-Armand Trousseau hospitals belonging to the same hospital group. The CRSA is made up of 13 research teams certified by Inserm and Sorbonne University and an administrative team, located mainly at the Saint-Antoine and Armand Trousseau hospitals.

 

Site/location and physical address

Saint Antoine Hospital – Sorbonne University
Kourilsky Building
34 rue Crozatier 75012 PARIS

 

Website

www.crsa.fr

 

Contact

Mail: cm.crsa@inserm.fr

Telephone: +33(0)1.49.28.46.00

 

Guardianship

INSERM and Sorbonne University

 

Director / Head of structure

FEVE Bruno

 

 

Research units

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Graft versus host disease after allogeneic hematopoietic stem cell transplantation

Our research team studies the immunological mechanisms and side effects of immunotherapy and targeted therapies in hematological malignancies.

https://www.crsa.fr/equipe-mohamad-mohty.html

 

Department

Oncology – Hematology

 

Manager / Team Leader

Mohamad Mohty

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Hematopoietic and leukemic development: diseases and cell therapy

The work carried out in the team addresses two fundamental aspects of hematology: the understanding of the mechanisms of development of acute myeloid leukemia (AML) and the study of hematopoiesis and erythropoiesis with a view to transfusion and cell therapy. Three groups are divided along these two axes while interacting closely.

https://www.crsa.fr/equipe-mohamad-mohty.html

 

Department

Oncology – Hematology

 

Manager / Team Leader

François Delhommeau

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TGF-β singularization in cellular plasticity and cancer

Transforming Growth Factor beta or TGF-B is a multifunctional cytokine that plays a key role in the biology of metazoans, from the early stages of embryogenesis to the regeneration of mature tissue. TGF-B maintains tissue homeostasis through a multitude of processes, such as regulation of pluripotency, stem cell differentiation, and suppression of the oncogenic capacity of premalignant cells. However, TGF-B may also exert pro-metastatic functions by promoting cell migration and invasion in later stages of cancer. However, the mechanisms by which TGF-B exerts this dual role during carcinogenesis remain poorly understood. In this context, our research projects aim at elucidating the interactions between key components of the TGF-B signaling pathway, in particular during tumor and metastatic progression and in cellular plasticity processes.

https://www.crsa.fr/equipe-celine-prunier.html

 

Department

Oncology – Hematology

 

Manager / Team Leader

Céline Prunier

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Biology and therapeutics of cancer

Our research focuses on the following areas:

• Tumor cell plasticity, in particular epithelial-mesenchymal transition (EMT) and stem cell phenotypes. The relationship between invasion, chemoresistance and immune cell recruitment. Role of CCN proteins
• The vascular tumor environment. Relationship between cancer and thrombosis. Vascular mimicry and circulating tumor cells.
• Development of new drugs or combination of drugs. Identification of prognostic or predictive biomarkers.

https://www.crsa.fr/equipe-michele-sabbah.html

 

Department

Oncology – Hematology

 

Manager / Team Leader

Michèle Sabbah

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Microsatellite instability and cancer

The topics for our research group are focused on the study of mismatch repair (MMR)-deficient human tumors that develop through a particular molecular pathway characterized by the genetic instability of numerous microsatellite repeat sequences throughout the genome (MSI tumors). Since founded, the research interest of our lab is the analysis of the genetics of MSI tumors whatever their localization. The overall aim of our activity is to investigate important pathophysiological aspects of MSI carcinogenesis. Questions and hypothesis, on the fundamental and clinical sides, related to this particular tumor type are deduced from the analysis of causes and functional consequences of the microsatellite instability process characteristics of these tumors.

https://www.crsa.fr/equipe-alex-duval.html

 

Department

Oncology – Hematology

 

Manager / Team Leader

Alex Duval

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Fibro-inflammatory diseases of metabolic and biliary origin of the liver

The team’s objective is to find new mechanisms, therapies and predictive tests for the progression or regression of liver diseases, whether they are rare diseases such as biliary diseases or very common diseases such as chronic viral hepatitis or non-alcoholic fatty liver disease (NAFLD). Cohort studies are being conducted to better define biliary diseases, including those caused by genetic defects in the phosphatidyl choline transporter, ABCB4. The mechanisms of ABCB4 trafficking and function, the effect of missense variants and the response of these variants to pharmacological agents, are analyzed using 3D structural modeling of the transporter, polarized cells and transgenic mice.

https://www.crsa.fr/equipe-chantal-housset.html

 

Department

Metabolism – Inflammation

 

Manager / Team Leader

Housset Chantal

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Gut microbiota and inflammation

The main objective of our team is to decipher the mechanisms underlying gut microbiota-host interactions in physiology and in various pathologies, in particular those associated with intestinal inflammation. Our team, co-directed by Philippe Seksik and Harry Sokol, is currently working on several aspects of the pathogenesis of chronic inflammatory bowel disease (IBD), a common disease affecting up to 1% of the population.

https://www.crsa.fr/equipe-philippe-seksik.html

 

Department

Metabolism – Inflammation

 

Manager / Team Leader

Philippe Seksik & Harry Sokol

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